Catherine J. Luke,Adrian Vilalta,Mary K. Wloch,Thomas G. Evans,Andrew J. Geall,Gretchen S. Jimenez
申请号:
US13250508
公开号:
US08821890B2
申请日:
2011.09.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention is directed to compositions and methods for enhancing the immune response of a human in need of protection against influenza virus (IV) infection by administering in vivo, into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an IV protein or a fragment, a variant, or a derivative thereof, or a protein encoded thereby. The polynucleotide is incorporated into the cells of the human in vivo, and an immunologically effective amount of an immunogenic epitope of an IV, or a fragment, variant, or derivative thereof is produced in vivo. The IV protein (in purified form or in the form of an inactivated IV vaccine) is also administered in an immunologically effective amount.