Micro-volume devices, systems, and associated methods that facilitate the injection or aspiration of precisely controlled volumes of materials at precisely controlled rates are provided. In one embodiment, a micro-volume device includes a syringe and a lead screw connected to a plunger of the syringe. A mechanical interface is connected to the lead screw and includes a first set of cams adjacent a proximal portion and a second set of cams adjacent a distal portion. A mechanism is configured to oscillate a structure in a direction parallel to a longitudinal axis of the lead screw such that one or more projections of the structure to alternatively engage cams of the first and second sets of cams in a manner that results in rotation of the mechanical interface in a single direction for highly controlled linear displacement of the plunger.
