process for the preparation of an anticancer agent, 1 - ((4- (4-fluoro-2-methyl-1h-indol-5-yloxy) -6-methoxy-quinolin-7-yloxy) methyl) cyclopropanamine, its crystalline form and its salts
A process for the preparation of an anticancer agent, 1 - ((4- (4-fluoro-2-methyl-1h-indol-5-yloxy) -6-methoxy-quinolin-7-yloxy) methyl) cyclopropanamine, its form Crystals and Their Salts', the present invention relates to a novel synthesizing process of 1 - ((4- (4-fluoro-2-methyl-1h-indol-5-yloxy) -6-methoxy-quinolin-7 (yloxy) methyl) cyclopropanamine (al3818). a stable crystalline form of a13818 was prepared. salts and crystalline forms of al3818 were also prepared. The anticancer and optometric activities of al3818 and its salts were tested. the new process was presented in scheme i.?processo para o preparo de um agente anticancerígeno, 1-((4-(4-fluoro-2-metil-1h-indol-5-iloxi)-6-metoxi-quinolin-7-iloxi)metil)ciclopropanamina, sua forma cristalina e seus sais?, a presente invenção refere-se a um novo processo de sintetização de 1-((4-(4-fluoro-2-metil-1h-indol-5-iloxi)-6-metoxi-quinolin-7-iloxi)metil)ciclopropanamina (al3818). foi preparada uma forma cristalina estável de a13818. os sais e as formas cristalinas de al3818 também foram preparados. as atividades anticancerígenas e optométricas do al3818 e de seus sais foram testadas. o novo processo foi apresentado no esquema i.
