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HLA-A*1101限制性WT1胜肽及含有該限制性胜肽之醫藥組成物
专利权人:
INC.;INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY
发明人:
SUGIYAMA, HARUO,杉山治夫
申请号:
TW096149840
公开号:
TWI417103B
申请日:
2007.12.25
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
The present invention relates to a HLA-A*1101-restricted WT1 peptide, and more particularly, to a peptide containing an amino acid sequence composed of nine contiguous amino acids derived from a WT1 protein, which has a binding ability to HLA-A*1101 molecule and has a CTL-inducing ability; and to a peptide dimer formed by combining two peptide monomers containing an amino acid sequence composed of nine contiguous amino acids derived from a WT1 protein with at least one cysteine residue via a disulfide bond, which has a binding ability to HLA-A*1101 molecule and has a CTL-inducing ability. The present invention further relates to a polynucleotide encoding the peptide and a pharmaceutical composition comprising the same for the treatment and/or prophylaxis of cancers.本發明係有關HLA-A*1101限制性WT1胜肽,詳細而言,係有關一種含有由源自WT1蛋白質之9個連續胺基酸所構成之胺基酸序列的胜肽,該胜肽具有與HLA-A*1101分子結合能力、且具有CTL誘導能力;以及有關一種以含有至少具有1個半胱胺酸殘基之源自WT1蛋白質之9個連續胺基酸所構成之胺基酸序列的2個胜肽單體經由二硫鍵而互相結合的胜肽二聚物,該胜肽二聚物具有與HLA-A*1101分子結合能力、且具有CTL誘導能力;本發明又有關編碼該胜肽之聚核苷酸、包含該等之癌症治療及/或預防用醫藥組成物等。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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