The invention relates to a device (1) for the cutaneous application of a substance (2) that comprises: a patch (3) containing said substance (2) and a single-use wrist strap (4) containing an irreversible attachment system for maintaining the substance (2) of the patch (3) against the skin of a subject.Linvention concerne un dispositif (1) pour lapplication cutanée dune substance (2), comprenant: -un patch (3) comprenant ladite substance (2) et5 -un bracelet (4) à usage unique comprenant un système de fixation irréversible permettant le maintien de la substance (2) du patch (3) contre la peau d un sujet.