(Wherein, X, and R 2 R 1, and is as described herein) processes for their preparation, the present invention provides medicaments containing them as well as 5-substituted benzoxazine derivative of the formula (I) their use as medicaments and compositions. Depression, anxiety disorders, schizophrenia, panic disorder, agoraphobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, pain, memory impairment, dementia, the active substance of the present invention, eating behavior disorders , sexual dysfunction, sleep disorders, substance abuse, is a 5-HT 5A receptor antagonist useful in the prevention and / or treatment of gastrointestinal disorders movement disorder, or mental disorders such as Parkinsons disease.本発明は、式(I)で示される5-置換ベンゾオキサジン誘導体(式中、X、R1及びR2は、本明細書に記載されたとおりである)ならびにそれらの製法、それらを含む医薬組成物及び医薬としてのそれらの使用に関する。本発明の活性物質は、鬱病、不安障害、統合失調症、パニック障害、広場恐怖症、対人恐怖症、強迫性障害、心的外傷後ストレス障害、疼痛、記憶障害、認知症、摂食行動障害、性機能障害、睡眠障害、薬物乱用、パーキンソン病のような運動障害、精神障害又は胃腸障害の予防及び/又は治療に有用な5-HT5A受容体アンタゴニストである。
