POUGNAS, JEAN-LUC,BROUSSAUD, OLIVIER,CALVET, NICOLAS,COMTAT, SOPHIE
申请号：
CA2657090
公开号：
CA2657090C
申请日:
2005.07.08
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention concerns a clear pharmaceutical aqueous emulsion composition which comprises Propofol and a surfactant system and which is particularly usable for a safe administration through intravenous injection. A composition according to the invention is characterized in that said surfactant system comprises in combination at least one pharmaceutically acceptable monovalent metal salt of a fatty acid having from 5 to 23 carbon atoms, and at least one polyethylene glycol hydroxystearate. This combination allows to use a mass ratio (w/w) surfactant system / Propofol which is less than 4 and preferably less than or equal to 2.8, while obtaining such a clear composition.
