Alexander Mackerell, Jr.,Hong Zhang,Andrei Osterman,Rohit Kolhatkar
申请号：
US13383340
公开号：
US08785499B2
申请日:
2010.07.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes.
