The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer’s disease and tauopathies.本發明涉及新穎種類的單株抗體,其特異性地結合病理性過度磷酸化(PHF)τ蛋白上的磷酸化絲胺酸396殘基(pS396),並且涉及在阿茲海默症和τ蛋白病變的治療中使用該等分子及它們的τ蛋白結合片段之方法。