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Medicine content fat emulsion and its production manner
专利权人:
テクノガード株式会社
发明人:
鍋田 喜一郎
申请号:
JP2009541177
公开号:
JP5340954B2
申请日:
2008.11.14
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The object is to provide: a fat emulsion containing a medicinal agent, which can be used as an injection preparation, an eye drop, a nose drop, an inhalation preparation or the like and which has transparency and excellent stability and a process for producing the fat emulsion. Specifically disclosed is a fat emulsion containing a medicinal agent, which comprises at least a poorly water-soluble medicinal agent, an oil-and-fat, an emulsifying agent and water, wherein the content of the oil-and-fat is 0.05 to 2 mg/mL and wherein the ratio of the medicinal agent to the oil-and-fat [(medicinal agent)/(oil-and-fat)] is 0.01 to 20 by weight (provided that the total amount of the medicinal agent and the oil-and-fat is up to 5 mg/mL), and wherein the ratio of the emulsifying agent to the oil-and-fat [(emulsifying agent)/(oil-and-fat)] is 1 to 300 by weight. Also specifically disclosed is a process for producing the fat emulsion, which comprises emulsifying the constituent components, wherein the content of the oil-and-fat is 0.05 to 2 mg/mL and wherein the ratio of the medicinal agent to the oil-and-fat [(medicinal agent)/(oil-and-fat)] is 0.01 to 20 by weight (provided that the total amount of the medicinal agent and the oil-and-fat is up to 5 mg/mL), and wherein the ratio of the emulsifying agent to the oil-and-fat [(emulsifying agent)/(oil-and-fat)] is 1 to 300 by weight.
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