The present invention relates to a pH buffered bioactive glass, and its preparation process and use. The pH buffered bioactive glass comprises SiO 2 , CaO, Na 2 O, and P 2 O 5 , and further comprises solid acidic particles or a Tris buffer solution. The pH buffered bioactive glass can regulate the pH of formulations comprising bioactive glass, and has a good therapeutic effect with a low dosage.