ФАРБЕР, БОРИС СЛАВИНОВИЧ;ФАРБЕР, СОФЬЯ БОРИСОВНА;БОРИС СЛАВИНОВИЧ;СОФЬЯ БОРИСОВНА
发明人:
Фарбер, Борис Славинович,Фарбер, Софья Борисовна,Мартынов, Артур Викторович,Борис Славинович,Софья Борисовна,Артур Викторович
申请号：
EA202090753
公开号：
EA202090753A1
申请日:
2017.06.16
申请国别(地区):
EA
年份:
2020
代理人:
摘要：
Scope: the invention relates to combinatorial chemistry, pharmacy and cosmetology, allows you to synthesize new combinatorial libraries of derivatives of antibiotics for use in pharmacy, cosmetology and pharmacy. The essence of the invention: new combinatorial derivatives of antibiotics based on supramolecular structures, characterized in that the supramolecular structures (B) are obtained by combinatorial synthesis of a polyfunctional antibiotic (A1) from one source molecule with two or more groups available for covalent modification in a reaction with at least two different modifiers (M2 and M3) at the same time according to the synthesis scheme m A1 + k M2 + k M3 = m B, this forms a combinatorial mixture of modified derivatives of the original molecule, with a maximum variety of derivatives, and as a biologically active substances to create pharmaceutical compositions use the whole combinatorial the mixture is in the form of a supramolecular structure without separation into individual components, and a combinatorial mixture of B modified derivatives of the original antibiotic molecule (A1) is formed in the reaction, the maximum number of combinations of which (m). EFFECT: modified combinatorial derivatives of antibiotics with antimicrobial and antifungal activity against multiresistant and multiresistant strains of microorganisms and fungi. Means have a wide spectrum of action, and the supramolecular and combinatorial structure of their tens and hundreds of derivatives eliminates the addiction of microorganisms.Область применения: изобретение относится к комбинаторной химии, фармации и косметологии, позволяет синтезировать новые комбинаторные библиотеки производных антибиотиков для применения в фармации, косметологии и фармации. Суть изобретения: новые комбинаторные производные антибиотиков на основе супрамолекулярных структур, отличающиеся тем, что супрамолекулярные структуры (B) получены путем комбинаторного синтеза из одной исходной молекулы полифункционально
