Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent formulated for extended-release.本發明公開了一種減少排尿頻率的方法和組合物。一種方法包括向有需求的個體施用有效量的包含配製成延長釋放製劑的鎮痛劑的醫藥組合物。另一種方法包括向有需求的個體施用有效量的包含多種配製為延長釋放的活性成分的醫藥組合物。另一種方法包括向有需求的個體施用有效量的利尿劑,然後另外施用包含配製為延長釋放的鎮痛劑的醫藥組合物。
