The present invention relates to certain 2- (2,4,5- replaces phenylamino) pyrimidine compound and its pharmaceutically acceptable salt, these compound or its salts can pass through EGF-R ELISA (such as L858R activated mutants body, Exon19 lack activated mutant body and T790M resistant mutants) treatment or prevention of what disease or the patient's condition of certain mutant forms. This compound and its salt can use the treatment or prevention of some various cancers of what. The invention further relates to be especially polymorphous pharmaceutical composition of useful these compounds and salt comprising the compound and its salt, can manufacture the intermediate of the compound with what and method using the compound and its salts for treating by the various different form EGFR diseases mediated.本發明涉及某些2-(2,4,5-取代苯氨基)嘧啶化合物及其藥學上可接受的鹽，這些化合物或其鹽可通過某些突變形式的表皮生長因子受體(例如L858R激活突變體、Exon19缺失激活突變體、和T790M抗性突變體)而用於疾病或病況的治療或預防。這種化合物及其鹽可用於一些不同癌症的治療或預防。本發明還涉及包含所述化合物及其鹽特別是有用的這些化合物和鹽的多晶型的藥物組合物、可用於製造所述化合物的中間體、以及利用所述化合物及其鹽治療由各種不同形式EGFR所介導的疾病的方法。
