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2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER
专利权人:
ASTRAZENECA AB
发明人:
BUTTERWORTH, SAM,FINLAY, MAURICE, RAYMOND, VERSCHOYLE,WARD, RICHARD, ANDREW,KADAMBAR, VASANTHA, KRISHNA,CHINTAKUNTLA, CHANDRASEKHARA, REDDY,MURUGAN, ANDIAPPAN,REDFEARN, HEATHER, MARIE,CHUAQUI, CLAUDIO
申请号:
MYPI 2013702541
公开号:
MY161925A
申请日:
2012.07.25
申请国别(地区):
MY
年份:
2017
代理人:
摘要:
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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