BILLEN, Denis,BIRCHMEIER, Matthew Joseph,VANDERROEST, Ronald J.
申请号：
ES13756985
公开号：
ES2671271T3
申请日:
2013.08.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A Crystalline Form A of (S) -1- (5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazol-3-yl) -3'Hespiro [azetidin-3,1'-isobenzofuran] -1-yl) -2- (methylsulfonyl) ethanone that has at least one of the following properties: a) an X-ray diffraction pattern that has characteristic peaks expressed in 2θ degrees ( ± 0.2 º) to approximately 17.18, 18.83 and 20.07； b) an X-ray diffraction pattern that has characteristic peaks expressed in degrees 2θ (± 0.2 º) at approximately 17.18, 18.83 and 20.07 and which also comprises at least one additional diffraction peak expressed in degrees 2θ (± 0.2 º) selected from the group consisting of peaks at approximately 4.70, 9.39, 14.10, 15.70, 19.12, 20.97, 21； 42, 22.03 , 22.54, 23.62 and 28.42； c) an X-ray diffraction pattern that has characteristic peaks expressed in degrees 2θ (± 0.2 º) at approximately 17.18, 18.83 and 20.07 and which further comprises at least one additional diffraction peak expressed in degrees 2θ (± 0.2 º) at approximately 21.42 and 28.42； d) an X-ray diffraction pattern that has characteristic peaks expressed in degrees 2θ (± 0.2 º) at approximately 17.18, 18.83, 20.07, 21.42, 22.54 and 28.42； e) a differential scanning calorimeter thermogram having a single predominant endotherm at approximately 145.53 ° C at a scanning rate of 10 ° C per minute, as shown in Figure 3.1； and f) a differential scanning calorimeter thermogram having a single predominant endotherm within the range of 144.01 to 146.92 ° C at a scanning rate of 10 ° C per minute, as shown in Figure 3.2.Una Forma cristalina A de (S)-1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3'Hespiro[ azetidin-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona que presenta al menos una de las siguientes propiedades: a) un patrón de difracción de rayos X que tiene picos característicos expresados en grados 2θ (± 0,2 º) a aproximadamente 17,18, 18,83 y 20,07； b) un patrón de difracción de rayos X que
