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CRYSTAL FORMS 1- (5 '- (5- (3,5-Dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3'N-spiro [Azetidine-3, 1'-Isobenzofuran] -1-yl) -2- (methylsulfonyl) ethanone
专利权人:
ЗОЭТИС СЕРВИСИЗ ЛЛС (US)
发明人:
БИЛЛЕН Денис (US),БЁЧМЕЙЕР Мэтью Джозеф (US),ВАНДЕРРОЕСТ Рональд Джей (US)
申请号:
RU2015107052
公开号:
RU2015107052A
申请日:
2013.08.28
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Crystalline Form A 1- (5 ′ - (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazol-3-yl) -3′H-spiro [azetidine -3,1′-isobenzofuran] -1-yl) -2- (methylsulfonyl) ethanone, exhibiting at least one of the following properties: a) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (± 0.2 °) at approximately 17.18, 18.83 and 20.07; b) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (± 0.2 °) at approximately 17.18, 18.83 and 20.07, and further containing at least one additional peak diffraction, expressed in degrees 2θ (± 0.2 °), selected from the group consisting of peaks at approximately 4.70, 9.39, 14.10, 15.70, 19.12, 20.97, 21.42 , 22.03, 22.54, 23.62 and 28.42; c) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (± 0.2 °) at approximately 17.18, 18.83, and 20, 07, and further comprising at least one additional diffraction peak expressed in degrees 2θ (± 0.2 °) at approximately 21.42, 22.54 and 28.42; d) an X-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (± 0.2 °) at approximately 17.18, 18.83, 20.07, 21.42, 22.5 4 and 28.42; e) the infrared spectrum with the Fourier transform in the 1800-600 cm range, in fact, as shown in FIG. 2; f) a differential scanning calorimetry thermogram having one predominant endotherm at approximately 145.53 ° C at a scanning speed of 10 ° C per minute, essentially as shown in FIG. 3.1; and g) a differential scanning calorimeter thermogram having one predominant endotherm in the range of 144.01 to 146.92 ° C. at a scanning speed of 10 ° C. per minute, essentially as shown in FIG. 3.2.2. The crystalline form according to claim 1, which has (i) at least one of the following x-ray diffraction patterns selected from a) an x-ray diffraction pattern having characteristic peaks expressed in degrees 2θ (± 0.2 °) at1. Кристаллическая форма А 1-(5′-(5-(3,5-дихлоро-4-фторфенил)-5-(трифторметил)-4,5-диг
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