A method for mechanically capturing and removing a thrombus from a blood vessel includes advancing a guidewire into the thrombus. A self-expanding body is allowed to expand in the blood vessel, wherein the self-expanding body is fixed to a distal end portion of an elongate catheter. The self-expanding body preferably includes a tapered proximal end portion and an open distal end while in the expanded configuration. The self-expanding body forms a mesh structure adapted for allowing blood to pass therethrough. The thrombus is captured by the self-expanding body and then retrieved into an aspiration catheter. Aspiration is preferably applied during and after retrieval of the thrombus into the aspiration catheter. A thrombolytic drug may be delivered into the blood vessel before capturing and retrieving the thrombus. In preferred methods of use, the thrombus is captured and removed for reducing health problems associated with a stroke.
