Yong Il Kim,Young Jun Na,Jun Young Choi,Min Jung Kim,Jae Hyun Park,Jong Soo Woo
申请号：
US13988947
公开号：
US20130243872A1
申请日:
2011.12.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided is a pharmaceutical composite formulation for preventing or treating cardiovascular diseases, which comprises (1) a first particle comprising an HMG-CoA reductase inhibitor and a basic additive and (2) a second particle comprising a core containing aspirin and an enteric coating layer coated on said core, wherein the difference in the average diameters of said first and second particles is 100 μm to 800 μm a method for preparing same and a method of validating the quality of same. The pharmaceutical composite formulation according to the present invention can improve the stability of an active ingredient and prevent adverse impacts between the active ingredients to thereby enable an accurate quality validation of the pharmaceutical composite formulation.
