Bispecific antibodies comprise first binding domain which binds to EGFR and a second binding domain which binds to PD-1, wherein the antibody or the antigen binding-fragment is in a format selected from the group consisting of single chain Fv (scFv), diabodies, and oligomers of the foregoing formats. Amino acid sequences of the antibodies, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies are provided. Therapeutic compositions comprising the antibodies and methods for treating cancers and other diseases with the bispecific antibodies are also provided.本發明提供雙特異性抗體，其包含結合於EGFR的第一結合結構域及結合於PD-1的第二結合結構域，其中，該抗體或其抗原結合片段係選自由單鏈抗體(scFv)、雙抗體及上述形式的寡聚物組成之群中的形式。本發明亦提供本發明抗體的胺基酸序列、選殖或表現載體、宿主細胞、以及用於表現或分離抗體的方法。亦提供包含本發明抗體的治療組合物。本發明亦提供用雙特異性抗體治療癌症及其他疾病的方法。
