RABOISSON, PIERRE JEAN-MARIE BERNARD,DE KOCK, HERMAN AUGUSTINUS,MC GOWAN, DAVID CRAIG,VAN DE VREKEN, WIM,HU, LILI,TAHRI, ABDELLAH,VENDEVILLE, SANDRINE MARIE HELENE
申请号：
ES07822656
公开号：
ES2470568T3
申请日:
2007.11.16
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the formula ** Formula ** and the salts and stereoisomers thereof, in which each dashed line (represented by - - - -) independently represents an optional double bond； X is N, CH, and when X has a double bond, it is C； R1 is -NH-SO2R8； R2 is hydrogen, and when X is C or CH, R2 can also be C1-6 alkyl； R3 is hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, C3-7 cycloalkyl； n is 3, 4, 5, or 6； R4 is C1-6 alkyl or C3-7 cycloalkyl； R5 represents hydrogen, halo, C1-6 alkyl, hydroxy, C1-6 alkoxy, polyhalo-C1-6 alkyl； R6 represents hydrogen, C1-6 alkoxy, mono- or dialkyl-C1-6-amino； or R5 and R6 may optionally, together with the carbon atoms to which they are attached, form a 6-membered, unsaturated or partially unsaturated ring, and wherein said ring may optionally comprise one or two heteroatoms selected from O, N and S； R7 is hydrogen； C3-7 cycloalkyl optionally substituted with C1-6 alkyl； or C1-6 alkyl optionally substituted with C3-7 cycloalkyl； R8 is C3-7 cycloalkyl optionally substituted with C1-6 alkyl； C1-6 alkyl optionally substituted with C3-7 cycloalkyl； or -NR8aR8b, in which R8a and R8b are each independently C1-6 alkyl, or R8a and R8b, together with the nitrogen to which they are attached, form a saturated 5- or 6-membered heterocyclic ring.Un compuesto que tiene la fórmula **Fórmula** y las sales y estereoisómeros del mismo, en la que cada línea discontinua (representada por - - - - ) representa independientemente un doble enlace opcional； X es N, CH, y cuando X posee un doble enlace, es C； R1 es -NH-SO2R8； R2 es hidrógeno, y cuando X es C o CH, R2 también puede ser alquilo de C1-6； R3 es hidrógeno, alquilo de C1-6, alcoxi de C1-6-alquilo de C1-6, cicloalquilo de C3-7； n es 3, 4, 5, ó 6； R4 es alquilo de C1-6 o cicloalquilo de C3-7； R5 representa hidrógeno, halo, alquilo de C1-6, hidroxi, alcoxi de C1-6, polihalo-alquilo de C1-6； R6 representa hidrógeno, alcoxi de C1-6, mono- o dialquil-C1-6-amino； o R5 y R6 pueden opcionalmente, junto con los
