Nuovo modello animale transgenico non umano per i disordini neuroinfiammatori della funzione motoria.

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专利权人:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

发明人:

RICCARDI, Carlo,BERESHCHENKO, Oxana,BRUSCOLI, Stefano,NERLOV, Claus

申请号：

ITUB20154009

公开号：

ITUB20154009A1

申请日:

2015.09.29

申请国别(地区):

IT

年份:

2017

代理人:

摘要：

A subject-matter of the present invention is a transgenic mouse model of neuroinflammatory disorders of motor function, in particular of demyelinating diseases, like multiple sclerosis, wherein the transgenic mouse is hemizygous and overexpresses a stabilized form of human beta-catenin from a single Rosa26 allele. A further subject- matter of the invention is the use of said model in the evaluation of potential pharmacological agents for the treatment of these pathologies, as well as diagnostic methods.

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