This invention provides a system and method for providing Indicator Features in high resolution micro-ultrasound prostate images, wherein the ultrasound device operates at a center frequency of 15 MHz and above. Indicator Features are features, which have been identified alone and/or in combination with other features in high resolution micro-ultrasound images, and have been determined to be significantly statistically correlated to either benign tissue or some grade of cancerous tissue on the basis of predictive probabilities. These Indicator Features can be used to train a linear or non-linear classifier, which can be used to classify patient images of the prostate. These Indicator Features can be used to guide a clinician as to where to take a biopsy core from the prostate, as well as assist in diagnosis of the tissue.
