FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new sulphonamide compounds of the structure as follows or to its pharmaceutically acceptable salt, wherein a bicyclic aromatic heterocycle consisting of pyridine condensed with benzene； one of Y and Z is CR2d, whereas the other one is a chemical bond； the ring B is (a) mono- or bicyclic aromatic hydrocarbon having 6-11 carbon atoms as circular atoms； (b) 5-11-merous mono- or bicyclic aromatic heterocycle containing carbon atoms and 1-4 heteroatoms specified in oxygen, sulphur and nitrogen atoms； or (c) 4-12-merous mono- or bicyclic non-aromatic heterocycle containing carbon atoms and 1-4 heteroatoms specified in oxygen, sulphur and nitrogen atoms； ring C: benzene, R1: (a) H； (b) C1-C6alkyl, which can be optionally substituted by 1-3 groups specified in halogen, oxo and hydroxy； (c) C3-C7cycloalkyl； (d) C1-C6alkoxy group； or (e) halogen； each of R2a, R2b, R2c and independently represents(a) H； (b) C1-C6 alkyl, which can be optionally substituted by 1-3 groups specified in C1-C6alkoxy group, halogen and hydroxy； (c) C3-C7cycloalkyl； (d) C1-C6alkoxy group； (e) phenyl； (f) 6-merous monocyclic aromatic heterocyclic group containing carbon atoms and 1-4 heteroatoms specified in oxygen, sulphur and nitrogen atoms； (g) 5-merous monocyclic non-aromatic heterocyclic group containing carbon atoms and 1-4 heteroatoms specified in oxygen, sulphur and nitrogen atoms； or (h) halogen, each of R3a, R3b, R3c and R3d independently means (a) H； (b) C1-C6alkyl, which can be optionally substituted by 1-7 groups specified in C3-C7cycloalkyl (wherein cycloalkyl can be optionally substituted by 1 group specified in C1-C6alkyl and C1-C6halogenalkyl), C1-C6alkoxy group, C1-C6halogenoalkoxy, halogen and hydroxy； (c) C3-C7cycloalkyl； (d) C1-C6alkoxy group, which can be optionally substituted by 1-3 groups specified in C3-C7cycloalkyl, C1-C6alkoxy group and halogen； (e) C3-C7cycloalkoxy group； (f) phenyl, which can be optionally subs
