STICHTING KATHOLIEKE UNIVERSITEIT;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人:
MULDER, WILLEM,OCHANDO, JORDI,FAYAD, ZAHI,NETEA, MIHAI,JOOSTEN, LEO
申请号：
CA3082830
公开号：
CA3082830A1
申请日:
2018.11.20
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to therapeutic nanobiologic compositions and methods of treating a patient affected by trained immunity to treat cancer or sepsis, to improve the efficacy of checkpoint inhibiter therapy, to provide long-term tumor remission, to treat defective trained immunity, and to provide PET imaging of radiolabeled nanobiologics to show the location of accumulation in tissue, where trained immunity is the long-term decreased responsiveness, the result of metabolic and epigenetic re-wiring of myeloid cells and their stem cells and progenitors in the bone marrow and spleen and blood.
