Timothy L. Macdonald;Thomas P. Mathews;Kevin R. Lynch;Yugesh Kharel;Brian R. Wamhoff
发明人:
Kevin R. Lynch,Timothy L. Macdonald,Yugesh Kharel,Thomas P. Mathews,Brian R. Wamhoff
申请号:
US12896881
公开号:
US08686046B2
申请日:
2010.10.02
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.