Lynn Macdonald,Andrew J. Murphy,Naxin Tu,Cagan Gurer,Vera Voronina,Sean Stevens
申请号：
US15615243
公开号：
US20170273286A1
申请日:
2017.06.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for making, and methods of making, the genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are also provided.
