Lynn MacDonald,Andrew J. Murphy,Naxin Tu,Cagan Gurer,Vera Voronina,Sean Stevens
申请号：
US13793935
公开号：
US09043996B2
申请日:
2013.03.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making the genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are provided.
