Jan Maarten Van Dijl,Girbe Buist,Hendrik Petrus Jozef Bonarius,Neeltje Margaretha Kooi,Goffe Sytse Elsinga,Herman Groen
申请号：
US15103586
公开号：
US09944694B2
申请日:
2014.12.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to the field of immunology and vaccine development. In particular, it relates to antibodies and fragments thereof against Staphylococcus aureus and to therapeutic and diagnostic uses thereof. Provided is an isolated antibody or a functional fragment thereof, which binds to an epitope of the Immunodominant Staphylococcal antigen A (IsaA), wherein said antibody comprises at least four Isa A epitope-binding CDR sequences selected from the group consisting of SEQ ID NO: 1； SEQ ID NO: 2； SEQ ID NO: 3； SEQ ID NO: 4； SEQ ID NO: 5； SEQ ID NO: 6, and functional equivalents thereof having an amino acid sequence that is at least 85% identical to an amino acid sequence of SEQ ID NO: 1-6.
