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Polymer derived from linear polyethylenimine for gene transfer
专利权人:
Philippe Guegan;Chantal Pichon;Hervé Cheradame;Patrick Midoux;Mathieu Sassatelli
发明人:
Hervé Cheradame,Mathieu Sassatelli,Philippe Guegan,Patrick Midoux,Chantal Pichon
申请号:
US12920971
公开号:
US08658150B2
申请日:
2009.03.04
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention relates to a static copolymer of linear polyethylenimine that comprises two monomer units of the following formulas I and II, in which R1 is a hydrogen atom or a C1-C6 alkyl radical, R2 is a hydrogen atom, a C1-C6 alkyl, aryl or aralkyl group, wherein the alkyl group is a C1-C6 one, n is a number between 1 and 99% of the total monomers, m is a number between 1 and 99% of the total monomers, and advantageously m+n=100%. The invention also relates to complexes of this copolymer with a nucleic acid, and to the use thereof in in vivo, in vitro or ex vivo gene transfection.
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