Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof

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专利权人:

Guangzhou Institutes of Biomedicine and Health; Chinese Academy of Sciences

发明人:

Yanmei Zhang,Ke Ding,Jinxi Liao,Yican Wang,Panyu Chen

申请号：

US14580509

公开号：

US09452220B2

申请日:

2014.12.23

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof:where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/