ShINE Klaus (DE),ШИНЕ Клаус (DE),BLOMS-FUNKE Petra (DE),БЛОМС-ФУНКЕ Петра (DE),SHINE KLAUS,BLOMS-FUNKE PETRA
申请号：
RU2008146815/04
公开号：
RU0002465263C2
申请日:
2007.04.25
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to a combination applicable for pain management, such as inflammatory pain, neuropathic pain, acute pain, chronic pain, visceral pain, migraine, cancer-associated pain. The combination contains: (a) at least one 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol of formula (I), optionally in the form of one of its individual stereoisomers, racemates or mixed stereoisomers, or in the form of a pharmaceutically acceptable acid-additive salt, or in the form of its solvate in the effective amount, and (b) one or more non-steroid anti-inflammatory preparations (NSAIP) specified in a group consisting of diclofenac, diclofenac sodium salt, metamizol, metamizol sodium salt, ibuprofen, ketoprofen, naproxen, (+)-ibuprofen, (-)-ibuprofen, (+)-naproxen in the effective amount. The ingredients of the combination may be introduced either simultaneously, or sequentially: the compound (a) is introduced before or after the compound (b) by the same or different methods. The invention also refers to a pharmaceutical salt formed by a cationic ingredient (a) of 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol of formula (I) and an anionic ingredient (b) of the acid non-steroid anti-inflammatory preparation (NSAIP) as well as to the compound of general formula (I") wherein the phenol hydroxyl group of the compound a) and the carboxyl group of the NSAIP forms a covalent bond.EFFECT: higher clinical effectiveness of the combination.29 cl, 2 tbl, 21 exНастоящее изобретение относится к комбинации, предназначенной для лечения боли, такой как воспалительная боль, невропатическая боль, острая боль, хроническая боль, висцеральная боль, мигрень, боли при раке. Комбинация включает: (а) по крайней мере, один 3-(3-диметиламино-1-этил-2-метилпропил)фенол формулы (I), необязательно в форме одного из его индивидуальных стереоизомеров, рацемата или смеси стереоизомеров, или в форме фармацевтически приемлемой кислотно-аддитивной соли, или в форме его сольвата
