UNIVERSITY OF VIRGINIA PATENT FOUNDATION;UNIVERSITY OF BIRMINGHAM
发明人:
HUNT, DONALD F.,SHABANOWITZ, JEFFREY,MALAKER, STACY A.,COBBOLD, MARK,PENNY, SARAH
申请号：
CA2995103
公开号：
CA2995103A1
申请日:
2016.08.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided are compositions that include one or more peptides, wherein each peptide is at least 8 amino acids long and has an amino acid sequence as set forth in any of SEQ ID NOs: 1-45. Also provided are in vitro populations of dendritic cells that include the disclosed compositions, in vitro populations of CD8+ T cells capable of being activated upon being brought into contact with the disclosed populations of dendritic cells, antibodies or antibody-like molecules that specifically bind to complexes of MHC class I molecules and the disclosed peptides, methods for treating and/or preventing cancer such as leukemia using the disclosed compositions and/or populations, methods for making cancer vaccines using the disclosed compositions, methods for screening target peptides for inclusion in an immunotherapy composition, methods for determining a prognosis of a leukemia patient, and kits that include at least one of the disclosed peptides.
