RYAN W. CHAU,COURTNEY A. CULLIS,MATTHEW O. DUFFEY,KRISTA E. GIPSON,YONGBO HU,GANG LI,TRICIA J. VOS,MICHAEL D. SINTCHAK
申请号：
ARP120104957
公开号：
AR089446A1
申请日:
2012.12.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. Characteristic 1: a formula compound (1) or a salt acceptable for the same agent, the characteristic of which is: - 1 km2 - g3-g83088-es-n = C-N-Cr =,=CR³-N-C=N-,=N-C=C-NR¹⁴-,o -NR¹⁴-C=C-N=；each occurrence of R¹⁴ is independently hydrogen, cyclopropyl, or an optionally substituted group selected from aliphatic C₁₋₆；The occurrence of R3 is independent hydrogen, CN, halogen, z-r83099,or an optionally substituted group selected from aliphatic C₁₋₆,and cycloaliphatic of 3 to 10 elements, wherein: Z is selected from an optionally substituted C₁₋₃ alkylene chain, -O-,-N (R) -- yes.-S (O) --S (O) --C (O) --co₂-,-c (o) NR --N (R) C (O) --N (R) CO --S (O) NR --N (R) S (O) --oc (o) N (R) --N (R) C (O) NR --N (R) S (O) N (R) -o -OC (O) -R³ᵃ is hydrogen or an optionally substituted aliphatic C₁₋₄, and R⁵ is hydrogen or an optionally substituted group selected from aliphatic C₁₋₆,cicloalif tico de 3 a 10 elementos heterociclilo de 4 a 10 elementos que tiene 1 - 5 hetero tomos seleccionados independientemente de nitr geno ox geno o azufre arilo de 6 a 10 elementos o heteroarilo de 5 a 10 elementos que tiene 1 - 5 hetero tomos seleccionados -C (O) OR-C (No. 830808) n (No. 830808)；-NHCOR⁴,-NHSO₂R⁴,-NHCON (R)-NHCOOR⁴,-NHSO N (R)-CH₂OR⁴,-CH N (R)-CH NHC (O) R-SO N (R)-C (O) NHC (3DNH) N (R)-NHSO₂OR⁴,or CY, wherein CY is an optionally substituted group selected from a cycloaliphatic of 3 to 7 elements； a heterocyclyl of 4 to 10 elements having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur； an aryl of 6 to 10 elements, or heteroaryl of 5 to 10 elements having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur； wherein: each R⁴ is independently selected from hydrogen, -OH, or an optionally substituted group selected from aliphatic C₁₋₆,cycloaliphatic of 3 to 10 elements, aryl of 6 to 10 elements, or heteroaryl of 5 to 10 elements having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur； or R⁴ is -Z²-R⁶ where: Z² is
