COATES, DAVID, ANDREW,DE DIOS MAGANA, ALFONSO,DE PRADO GONZALES, ANA,DEL PRADO CATALINA, MIRIAM FILADELFA,GARCIA PAREDES, MARIA, CRISTINA,GELBERT, LAWRENCE, MARK,KNOBELOCH, JOHN, MONTE,MARTIN DE LA NA
申请号：
NZ59311409
公开号：
NZ593114A
申请日:
2009.12.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are compounds of Formula I, salts thereof, and methods for their preparation. The compounds comprise pyridinyl, pyrimidinyl and benzimidazolyl moieties. Specific examples of compounds of Formula I include: [5-(4-Ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine, [5-(4-Ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine methanesulfonate, and [4-(3-Cyclopropyl-7-fluoro-2-methyl-3H-benzoimidazol-5-yl)-5-fluoro-pyrimidin-2-yl]-5-(1-ethyl-piperidin-4-ylmethyl)-pyridin-2-yl]-amine. Compounds of formula I are useful for treating colorectal cancer, breast cancer, lung cancer, prostate cancer, glioblastoma, mantel cell lymphoma, chronic myeloid leukaemia and acute myeloid leukaemia.
