The present invention relates to a novel aminopyridyloxypyrazole compound that inhibits the activity of transforming growth factor beta receptor 1 (TGFβR1), a pharmaceutical composition containing the compound, and the use of the compound to treat cancer, preferably colon cancer, black The method of tumor, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer and gastric cancer and/or fibrosis, preferably liver fibrosis and chronic kidney disease.本發明涉及抑制轉化生長因子β受體1(TGFβR1)的活性的新的氨基吡啶基氧基吡唑化合物、包含所述化合物的藥物組合物和採用所述化合物來治療癌症、優選結腸癌、黑素瘤、肝細胞癌、腎癌、成膠質細胞瘤、胰腺癌、骨髓發育不良綜合徵、肺癌和胃癌和／或纖維化、優選肝纖維化和慢性腎臟疾病的方法。
