MARSHALL CHRISTOPHER PATRICK,ALFF PETER JOSEPH,BERTUCCIOLI CLAUDIO,YONDOLA MARK ANDREW
申请号：
IN201627003556
公开号：
IN201627003556A
申请日:
2016.02.01
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
In some embodiments the present invention provides influenza hemagglutinin (HA) polypeptides proteins and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation even if the head domain of the HA protein is removed or disrupted. In some embodiments the present invention provides compositions comprising such polypeptides proteins and protein complexes and methods of use of such proteins and compositions for example as vaccine immunogens.
