A moisture-resistant multi-phase orthopedic system including a moisture-impervioussleeve, a moldable splint including a covered resin-impregnated substrate, anelongate removablewrap for retaining the splint on the limb, and a removable cast forapplication to the limb duringa subsequent treatment phase including a cast body haying an interior side andexterior side andcomprising a single layer, three-dimensional knitted fabric having an openstructure forproviding enhanced moisture transfer from the skin outwardly into theatmosphere and a flapcarried by the body and movable between an open position and a closed positionoverlying a partof the cast body to be applied to a treatment area of the limb, the flapadapted to cover and retainbetween the cast body and the flap the splint worn by the patient during theinitial treatmentphase in the same position as the location of the splint during the initialtreatment phase. Amethod of immobilizing a limb in multiple treatment phases utilizing the multi-phase orthopedicsystem.