HONG, KEELUNG,洪基隆,KAO, HAO WEN,高颢文,高顥文,LIN, YI YU,林宜谕,林宜諭,GUO, LUKE S. S.,郭松声,郭松聲
申请号：
TW107130015
公开号：
TW201919598A
申请日:
2018.08.28
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with entrapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure containing an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.提供一麻醉劑組成物，用於將醯胺類麻醉劑局部地施用於需要的個體。此麻醉劑組成物包含包埋醯胺類麻醉劑的多層囊泡，係經由以酸鹼值高於5.5的水性緩衝溶液將一高包埋性脂質結構水合製備而得，其中該高包埋性脂質結構含有醯胺類麻醉劑與脂質混合物。亦提供一種製備麻醉劑組成物的方法，相較於現有技術較為簡單，更易進行大規模製造，且可獲得高醯胺類麻醉劑相對於磷脂量的莫耳比例。這種麻醉劑組成物適於傳遞藥物並具有延長藥效時間的能力。
