Non-human animal model i.e. pig, with post-embolic pulmonary hypertension for screening e.g. tadalafil, has pulmonary arterial territories with adhesive tissue, where artery to lung is ligated in opposed manner
ASSOCIATION MARIE LANNELONGUE;ASSOCIATION MARIE LANNELONGUE
发明人:
FADEL ELIE,ELIE FADEL,MERCIER OLAF,OLAF MERCIER
申请号：
FR1151655
公开号：
FR2972100A1
申请日:
2011.03.01
申请国别(地区):
FR
年份:
2012
代理人:
摘要：
The model has a set of pulmonary arterial territories, where one of the set of pulmonary arterial territories has an adhesive tissue e.g. Dermabond(RTM: Cyanoacrylate tissue adhesive), and an artery to a lung is ligated in an opposed manner. An average pulmonary artery pressure is higher than or equal to 25mm mercury (Hg), pulmonary pressure of occluded artery is lower or equal to 15mm Hg, and pulmonary capillary pressure is lower or equal to 15mm Hg. Independent claims are also included for the following: (1) a method for screening drug candidates on a non-human animal (2) a method for studying physiopathology of post-embolic pulmonary hypertension on a non-human animal.La présente invention décrit un modèle animal présentant toutes les caractéristiques d'une hypertension pulmonaire post-embolique, ce qui fait de lui un modèle idéal pour étudier la physiopathologie de cette maladie, ou encore pour identifier des candidats médicaments efficaces permettant de la traiter.
