YANG, PAN CHYR,杨泮池,楊泮池,LAI, WEI YUN,赖薇云,賴薇云,PECK, KONAN,白果能,白果能,CHANG, CHENG JU,张真如,張真如,CHEN, CHI YUAN,陈琦媛,陳琦媛,YANG, SHUENN CHEN,杨顺贞,楊順貞
申请号：
TW103106607
公开号：
TW201527530A
申请日:
2014.02.26
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.本發明提供去氧核糖核酸酶,其能在對偶基因專一性的層級靜默EGFR表現。此等抗EGFR T790M突變之對偶基因專一性的去氧核糖核酸酶,使EGFR T790M mRNA的表現減量(knockdown)同時維持EGFR野生型mRNA之完整性。因此,此等抗EGFR T790M突變之對偶基因專一性的去氧核糖核酸酶可克服T790M驅動之TKI抗藥性並且伴隨降低在肺癌病患之正常細胞中不希望的副作用。
