Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.La présente invention concerne des systèmes et composition à base de Zotarolimus qui sont plus sûrs, plus efficaces, et produisent moins dinflammation que les systèmes à base de Rapamycine et de Paclitaxel. Linvention concerne également des dispositifs médicaux comprenant des structures supports capables de renfermer ou de servir de support à un vecteur ou excipient pharmaceutiquement admis susceptible de contenir au moins un agent ou une substance thérapeutique. En loccurrence, la surface de ce vecteur comporte un revêtement renfermant les composés thérapeutiques tels que des médicaments. Les structures supports considérées sont notamment les stents coronariens, les stents périphériques, les cathéters, les greffons artéro-veineux, les greffons dérivations, et les ballonnets dadministration médicamenteuse utilisés dans le système vasculaire. Ces compositions et
