JOEL C. REINHARDT,LYNN MACDONALD,RICHARD TORRES,MARC R. MORRA,JOEL H. MARTIN
申请号：
BRPI0815370
公开号：
BRPI0815370A2
申请日:
2008.08.08
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K D of 5 pM or less and does not cross-react with neurotrophin-3 (NT-3). The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
