Embodiments described herein relate to a refrigerator including a defrost chamber for defrosting food. The defrost chamber is fluidly coupled to the ambient air surrounding the refrigerator so that the chamber can be selectively returned to ambient temperature during a defrost cycle in order to defrost food. A control module can be included to activate a defrost cycle after a predetermined amount of time, or in advance of a desired meal time. The control module can automatically determine an anticipated defrost duration, given an input weight and type of stored food. Therefrom, the control module can activate the defrost cycle sufficiently in advance of the desired meal time to ensure that food has adequately defrosted for use. Further, after the defrost cycle has elapsed, cooling can be automatically reactivated in order to avoid food spoilage.