CARNEGIE INSTITUTE OF WASHINGTON;CARNEGIE INST OF WASHINGTON
发明人:
FIRE ANDREW,KOSTAS STEPHEN,MONTGOMERY MARY,TIMMONS LISA,XU SIQUN,TABARA HIROAKI,DRIVER SAMUEL E.,MELLO CRAIG C.
申请号：
US19980215257
公开号：
US6506559(B1)
申请日:
1998.12.18
申请国别(地区):
美国
年份:
2003
代理人:
摘要：
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
