A vehicle drunk driving warning and prevention system includes a wine measuring unit and a central control unit. The central control unit includes a one-person vehicle inspection module, a wine measurement judgment module and a vehicle opening and closing module. The man-car inspection module can inspect one of the sensing signals installed on the safety helmet or the seat belt and the seat cushion to activate the wine testing unit to detect whether the driver is drinking alcohol. When the wine testing judgment module is based on the wine When the test unit detects the result and judges that the driver is drinking, the vehicle opening and closing module cannot actuate the vehicle's starting device to turn on; otherwise, the vehicle's starting device is turned on.一種車輛酒駕警示與預防系統,包含一酒測單元以及一中央控制單元。該中央控制單元包括一人車檢視模組、一酒測判斷模組以及一車輛啟閉模組。該人車檢視模組能檢視安裝在安全帽或安全帶以及座墊上的感知元件之一感知訊號而致動該酒測單元偵測駕駛是否有飲酒,當該酒測判斷模組依據該酒測單元偵測之結果並判斷該駕駛有飲酒時,該車輛啟閉模組無法致動車輛的啟動裝置開啟;反之,開啟車輛的啟動裝置。