Institut Curie;ABIVAX;UNIVERSITE DE MONTPELLIER;Centre National de la Recherche Scientifique
发明人:
申请号：
EP18306782.6
公开号：
EP3669873A1
申请日:
2018.12.20
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present disclosure relates to quinoline derivatives of Formula (I):wherein each R is independently hydrogen, halogen, -CN, hydroxyl, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, (C3-C6)cycloalkyl, -NO2, -NR1R2, (C1-C4)alkoxy, phenoxy, -NR1-SO2-NR1R2, -NR1-SO2-R1, -NR1-C(=O)-R1, -NR1-C(=O)-NR1R2,-SO2-NR1R2, -SO3H, -O-SO2-OR3, -O-P(=O)-(OR3)(OR4), -O-CH2-COOR3, (C1-C3)alkyl, said alkyl being optionally mono- or di-substituted by a hydroxyl group； each R' is independently hydrogen, (C1-C3)alkyl, hydroxyl, halogen, -NO2, -NR1R2, morpholinyl, morpholino, N-methylpiperazinyl, (C1-C3)fluoroalkyl, (C1-C4)alkoxy, -O-P(=O)-(OR3)(OR4), -CN, or other groups； for use for preventing and/or treating inflammatory disease, disorder, or conditions.
