The present invention relates to an enteric drug of duloxetine, and more specifically, to an enteric drug which contains duloxetine or its salt, which are unstable under an acidic condition and an enteric layer containing polyvinyl acetate phthalate. The enteric drug of duloxetine according to an embodiment of the invention comprises 35-45 wt% of an inert core, 20-35 wt% of a drug layer, 15-25 wt% of a separating layer containing hydroxypropylmethylcellulose, 5-15 wt% of an enteric layer containing polyvinyl acetate phthalate, and 5-15 wt%of a finish layer.COPYRIGHT KIPO 2014[Reference numerals] (AA) % Dissolution (BB) Time (minutes) (CC) Cymbalta capsule (DD) Example 1 (EE) Example 2 (FF) Example 3본 발명은 둘록세틴의 장용성 제제에 관한 것으로서, 더욱 상세하게는 pH 산성 조건에서 불안정한 둘록세틴 또는 그 염을 폴리비닐아세테이트 프탈산이 장용층에 포함된 다층 구조로 제제화하여 안정화시킨 장용성 제제에 관한 것이다.
