CHUANG, TSUNG HSIEN,庄宗宪,莊宗憲,TANG, MING CHI,汤铭吉,湯銘吉,CHEN, SUNG JEN,陈颂仁,陳頌仁
申请号：
TW105131087
公开号：
TW201813643A
申请日:
2016.09.26
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention relates to an enteric-coated medicinal composition of duloxetine and a method of making the same. The enteric-coated medicinal composition of duloxetine includes a core, a drug layer covering the core, an isolation layer covering the drug layer, and an enteric coating layer covering the isolation layer. An amount of hydrophilic polymer can be controlled, thereby obtaining the enteric-coated medicinal composition of duloxetine with decreasing a yield of impurities formed in an acidic condition and exhibiting a drug release efficiency comparably to commercially available products.本發明有關於一種杜洛希酊腸衣包覆醫藥組成物及其製造方法。此杜洛希酊腸衣包覆醫藥組成物包含核心、包覆核心之藥物層、包覆藥物層之隔離層以及包覆隔離層之腸衣層。藉由控制隔離層的親水性聚合物之含量,可有效減少杜洛希酊腸衣包覆醫藥組成物在酸性環境下形成不純物的量,且其藥物釋出效率與市售產品相當。101/103/105‧‧‧曲線
