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RECIPE FOR Oral Transmucosal Administration of Hypolipidemic Drugs
专利权人:
МОРИ Марк (FR);ПЕРОВИЧ Филипп (FR)
发明人:
ПЕРОВИЧ Филипп (FR),МОРИ Марк (FR)
申请号:
RU2011130508/15
公开号:
RU2011130508A
申请日:
2009.12.17
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A formulation for oral transmucosal administration containing a lipid-lowering drug and / or an active agent for protecting the cardiovascular system, including: said lipid-lowering drug and / or an active agent for protecting the cardiovascular system; an aqueous-alcoholic solution consisting of water and ethanol with an alcohol strength of 30 °, in which said active substance is present in a stable and completely dissolved state; optionally, a pH correction agent and / or an antioxidant. 2. The formulation according to claim 1, characterized in that the agent for adjusting the pH is selected from sodium carbonate and bicarbonate, monosubstituted or disubstituted sodium phosphate, triethanolamine, sodium hydroxide (NaOH) and potassium hydroxide (KOH), as well as hydrochloric, sulfuric, phosphoric, citric , malic, lactic, succinic, and / or butyric acid. 3. The formulation according to claim 1 or 2, characterized in that the antioxidant is selected from vitamins E and C.4. The formulation according to claim 1 or 2, characterized in that the active substance is in the form of a base, and the pH correction agent is an acid. The formulation according to claim 1 or 2, characterized in that the active substance is in the form of a base, and the agent for adjusting the pH is the base. The formulation according to claim 1 or 2, characterized in that the pH is in the range of 5.0-9.0.7. The formulation according to claim 6, characterized in that the pH is in the range of 5.5-7.5.8. The formulation according to claim 1 or 2, characterized in that the alcohol strength in a water-alcohol solution is 30-70 °. 9. The formulation according to claim 1 or 2, characterized in that the water-alcohol solution contains 30-90 vol.% Alcohol and 10-70 vol.% Water. The formulation according to claim 11. Рецептура для перорального трансмукозального введения, содержащая гиполипидемическое лекарственное вещество и/или активное средство для защиты сердечно-сосудистой системы, включающая:ука
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中国工程科技知识中心
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